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Coenzyme Q10 100mg (120 capsules) - Patients' Own Nutrition

Coenzyme Q10 100mg (120 capsules)

£19.99

  • Helps produce energy from food
  • Taking a CoQ10 dietary supplement for ME/CFS or Fibromyalgia gives the immune system a boost
  • Powerful antioxidant
  • Fights free radicals
  • FREE UK and Ireland shipping when you spend £30 or more. More details here

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Description

Patients’ Own Coenzyme Q10

Coenzyme Q10 (known as CoQ10) is a substance which helps to procure energy from food. It is also a powerful antioxidant, which helps to boost immunity by increasing the number of particular immune cells present in the body. For these reasons, taking a CoQ10 dietary supplement for Chronic Fatigue Syndrome and Fibromyalgia is recommended.

Following the age of 20, levels of CoQ10 begin to fall as dietary CoQ10 is absorbed less efficiently from the intestines. Low levels of CoQ10 mean that cells do not receive all the energy they require.

CoQ10 is one of the most popular supplements for Chronic Fatigue Syndrome and Fibromyalgia patients, due to its positive impact on energy production, fighting free radicals and immunity.

The following Chronic Fatigue Syndrome specialists recommend taking Coenzyme Q10 dietary supplements for CFS: Dr Cheney, Dr Teitelbaum, Dr Pall, Dr Downing-Orr and Dr Myhill.

The science behind treating CFS and Fibro with CoQ10

Co-enzyme Q10 significantly reduces fatigue in ME/CFS patients

A 2015 Spanish randomized, double-blind placebo-controlled trial study evaluated the benefits of CoQ10 and NADH supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients. They found that NADH combined with Coenzyme Q10 significantly improved fatigue compared with the placebo group. In addition, a recovery of the biochemical parameters was also reported.

A study published in Clinical Nutrition in 2016 assessed whether NADH and Coenzyme Q10 supplementation showed a significant reduction in maximum heart rate after a cycle ergometer test. The 8-week, randomized, controlled, double-blind trial was conducted on 80 Chronic Fatigue Syndrome patients. The CoQ10 plus NADH group showed a significant reduction in max HR during a cycle ergometer test at week 8 versus baseline. Perception of fatigue also showed a decrease through all follow-up visits in active group versus placebo.

Chronic Fatigue Syndrome patients have low levels of CoQ10

A 2009 study conducted by Maes et al. assessed plasma CoQ10 levels in 58 patients with ME/CFS and in 22 normal controls and the relationships between CoQ10 and the severity of ME/CFS. They discovered that plasma CoQ10 was significantly lower in ME/CFS patients than in healthy controls. Furthermore, there was a significant inverse relationship between CoQ10 levels and fatigue and autonomic symptoms. The authors conclude that CoQ10 depletion plays a role in the pathophysiology of ME/CFS and suggest that patients would benefit from CoQ10 supplementation.

Co-Enzyme Q10 supplements can reduce symptoms in Fibro patients

Cordero et al. 2012 examined oxidative stress and bioenergetic status in blood mononuclear cells (BMCs) and its association to headache symptoms in 20 Fibromyalgia (FM) patients and 15 healthy controls. They found decreased CoQ10, catalase and ATP levels in BMCs from FM patients as compared to normal controls. Significant negative correlations between CoQ(10) or catalase levels in BMCs and headache parameters were also observed. Oral supplementation of COQ10 restored biochemical parameters and significantly improved clinical and headache symptoms. This study followed two pilot studies conducted by the same authors which also found CoQ10 deficiencies in FM patients and an improvement in symptoms after oral supplementation and restoration of CoQ10 levels.

A 2013 trial by Cordero et al. investigated the effect of CoQ10 supplementation on Fibromyalgia (FM) patients. A randomized, double-blind, placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ10 supplementation (300 mg/day) on 20 FM patients was undertaken. An important clinical improvement was evident after CoQ10 versus placebo treatment showing a reduction of pain, fatigue, and morning tiredness. Furthermore, an important reduction in tender points, including recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis, and gene expression levels was observed. The authors conclude that CoQ10 has a potential therapeutic effect in Fibromyalgia, and indicate new potential molecular targets for the therapy of this disease.

A 2002 trial published in The Journal of International Medical Research evaluated the efficacy of CoQ10 and ginkgo biloba supplementation on Fibromyalgia patients. Subjects were given oral doses of 200 mg coenzyme Q10 and 200 mg Ginkgo biloba extract daily for 84 days. Quality of life was measured using seven different subjective responses at monthly intervals. A progressive improvement in the quality-of-life scores was observed over the study period and at the end, the scores showed a significant difference from those at the start. This was matched by an improvement in self-rating with 64% claiming to be better.

A Low level of CoQ10 is found in Fibromyalgia patients

In 2014, Cordero et al. investigated the role of coenzyme Q10 (CoQ10) deficiency and mitochondrial dysfunction in immune activation in Fibromyalgia (FM) patients. Mitochondrial dysfunction was accompanied by increased levels of pro-inflammatory cytokines. A placebo-controlled trial of CoQ10 in FM patients led to reduced immune activation.

In 2013, Alcocer-Gomez et al. conducted a small study on four Fibromyalgia patients. All patients showed CoQ10 deficiency and improvement in clinical symptoms across all evaluation methods after CoQ10 supplementation.

 

 

Ingredients

Active Ingredients

Co-Enzyme Q10 Powder 100mg

Other Ingredients

HPMC Vegetarian Capsule, Rice Flour Powder

Our Quality

All of our products are manufactured in the UK to GMP code of practice and ISO 9001 quality assurance certification.

Directions

The recommended dose of our CoQ10 dietary supplement for Chronic Fatigue Syndrome and Fibromyalgia patients is one to three capsules per day or as advised by your specialist practitioner or doctor. For maximum absorption, take with food alongside Patients’ Own Fish Oil and Multivitamin. Coenzyme Q10 also works synergistically with Patients’ Own Acetyl-L-CarnitineNADH and D-Ribose. You should always check with your doctor or pharmacist before taking new supplements.

References

Castro-Marrero J., et al. “Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?Antioxid Redox Signal. 2015 Mar 10;22(8):679-85. doi: 10.1089/ars.2014.6181

Castro-Marrero J., et al. “Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial.Clin Nutr. 2016 Aug;35(4):826-34. doi: 10.1016/j.clnu.2015.07.010.

Maes M., et al. “Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder.” Neuro endocrinology letters 2009, 30:470-476

Cordero MD., et al. “NLRP3 inflammasome is activated in fibromyalgia: The effect of coenzyme Q10.” Antioxidants Redox Signal 2013; In Press.

Cordero MD., et al. “Can coenzyme Q10 improve clinical and molecular parameters in fibromyalgia?” Antioxidants Redox Signal 2013;19:1356-1361.

Cordero MD., et al. “Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement.” PLoS One. 2012;7(4):e35677. doi: 10.1371/journal.pone.0035677. Epub 2012 Apr 19.

Cordero MD., et al. “Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients.” Mitochondrion. 2011 Jul;11(4):623-5. doi: 10.1016/j.mito.2011.03.122. Epub 2011 Apr 7.

Cordero MD., et al. “Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment.” Clin Biochem. 2012 Apr;45(6):509-11. doi: 10.1016/j.clinbiochem.2012.02.001. Epub 2012 Feb 10.

Alcocer-Gomex E., et al. “Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review.” Nutrition. 2013 Nov-Dec;29(11-12):1422-5. doi: 10.1016/j.nut.2013.05.005.

Lister RE. “An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome.” The Journal of International Medical Research. 2002 Mar-Apr;30(2):195-9

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