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N-Acetyl-Cysteine Powder (500 grams) - Patients' Own Nutrition

N-Acetyl-Cysteine Powder (500 grams)

£39.99 £29.99

  • Our NAC supplement for ME/CFS and Fibromyalgia is 100% pure. We don’t add preservatives, additives, colorants, fillers or bulkers
  • N-Acetyl-Cysteine is critical for making a key antioxidant, Glutathione, and for keeping Vitamin C and E in their active forms
  • Taking a NAC supplement for ME/CFS reduces post-exertional malaise and increases time to muscle fatigue
  • NAC reduces the frequency and severity of colds and flu
  • FREE UK and Ireland shipping when you spend £30 or more. More details here

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Patients’ Own N-Acetyl-Cysteine

N-Acetyl-Cysteine (known as NAC) is absolutely essential for creating a key antioxidant, Glutathione, and for keeping Vitamins C and E in their active forms.

Many leading Chronic Fatigue Syndrome and Fibromyalgia researchers and doctors believe that Glutathione deficiency may be one of the major root causes of CFS and Fibromyalgia making the addition of a N-Acetyl-Cysteine supplement for these diseases of paramount importance.

When combined with L-Glutamine, N-Acetyl-Cysteine can help to significantly increase glutathione levels, making this combination of supplements ideal for Chronic Fatigue Syndrome and Fibromyalgia patients. NAC is also a popular choice for ME/CFS patients as it has the ability to increase time to muscle fatigue as well as reduce post-exertional malaise.

The Chronic Fatigue Syndrome specialists Dr Teitelbaum and Dr Downing-Orr recommend taking an NAC supplement for CFS/ME.

The science behind treating CFS and Fibro with N-Acetyl-Cysteine

NAC increases glutathione and reduces CFS symptoms

A recent study by Cornell University and the Mount Sinai Medical Center in New York assessed whether supplementing Chronic Fatigue Syndrome patients with N-Acetyl-Cysteine (1,800 mg) daily for 4 weeks would increase cortical glutathione compared to baseline. The authors previously reported a 36% deficit of glutathione in patients with Chronic Fatigue Syndrome compared to healthy controls. In this study, cortical glutathione levels were 15% lower in Chronic Fatigue Syndrome patients than in healthy controls. Following 4 weeks of daily NAC supplementation, cortical glutathione levels rose significantly in Chronic Fatigue Syndrome patients to match the healthy controls. Finally, N-Acetyl-Cysteine supplementation markedly improved symptoms in Chronic Fatigue Syndrome patients.

NAC reduces inflammation and leads to clinical improvement or remission in CFS and Fibro

A 2008 study published in the peer-reviewed Neuroendocrinology Letters analysed inflammatory markers and Fibromyalgia and Chronic Fatigue Syndrome rating, before and after intake of natural anti-inflammatory and anti-oxidative substances (NAIOSs), including L-glutamine, N-acetyl-cysteine and zinc, in conjunction with a leaky gut diet during 10-14 months. They found that intake of those NAIOSs significantly reduced inflammation resulting from leaky gut. Up to 24 of the 41 patients showed a significant clinical improvement or remission 10-14 months after intake of NAIOSs.

N-Acetyl-Cysteine improves athletic performance and could reduce post-exertional malaise

A 1994 placebo controlled study assessed the effect of N-Acetyl-Cysteine on healthy volunteers undergoing an extended fatiguing bout of electrical stimulation of the ankle dorsiflexors. They found that NAC significantly increased force output of approximately 15% after 3 minutes of repetitive contractions which persisted throughout the 30 minute protocol. The authors concluded that N-Acetyl-Cysteine resulted in improved performance suggestive of oxidative stress having a causal role in the fatigue process. As post-exertional malaise is one of the key symptoms found in CFS, this study suggests N-Acetyl-Cysteine supplementation may attenuate this.

Medved et al. (2004) investigated the effects of N-Acetyl-Cysteine on muscle cysteine, cystine, and glutathione and on time to fatigue during prolonged, submaximal exercise in endurance athletes. The study found that N-Acetyl-Cysteine improved performance in well-trained individuals, with enhanced muscle cysteine and glutathione availability a likely mechanism.

N-Acetyl-Cysteine delays fatigue and supports glutathione homeostasis

After observing N-Acetyl-Cysteine inhibiting fatigue during other tasks, Matuszczak et al. (2005) tested its effects during a handgrip exercise. They found that during repetitive submaximal efforts, NAC delayed fatigue (130% baseline) and inhibited glutathione oxidation. They go on to conclude that the data indicates that N-Acetyl-Cysteine supports glutathione homeostasis in exercising humans and may delay muscle fatigue during repetitive handgrip exercise. The findings support oxidative stress as a causal factor in human muscle fatigue and argue for larger translational studies to define NAC effects on human performance.

Intense exercise leads to post-exercise lymphocytopenia and immunosuppression, possibly by triggering lymphocyte apoptosis. Quadrilatero et al. (2004) tested the role of oxidative stress on exercise-induced lymphocyte apoptosis by administering N-Acetyl-Cysteine and measured apoptosis in intestinal lymphocytes (IL) from exhaustively exercised animals. N-Acetyl-Cysteine injection in mice maintained intracellular glutathione levels, prevented phosphatidylserine externalization, mitochondrial membrane depolarization, and loss of IL immediately and 24 h after exercise. These data suggest that lymphocyte apoptosis precedes post-exercise lymphocytopenia and may be due to oxidative stress.


100% Pure N-Acetyl-L-Cysteine Powder

All of our products are manufactured in the UK to GMP code of practice and ISO 9001 quality assurance certification.


The recommended dose for CFS patients is 600-1000mg daily for four months, followed by a maintenance dose of 250mg. Take on an empty stomach, 30 minutes before eating. For maximum benefit combine with Patients’ Own L-Glutamine.


Maes M., et al. “Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria,” Neuro Endocrinol Lett. 2008 Dec;29(6):902-10

Reid M., et al. “N-acetylcysteine inhibits muscle fatigue in humans,” J Clin Invest. 1994 Dec; 94(6): 2468–2474.

Matuszczak Y., et al. “Effects of N-acetylcysteine on glutathione oxidation and fatigue during handgrip exercise,” Muscle Nerve. 2005 Nov;32(5):633-8.

Medved I., et al. “N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals,” J Appl Physiol (1985). 2004 Oct;97(4):1477-85. Epub 2004 Jun 11.

Quadrilatero J., et al. “N-Acetyl-L-cysteine prevents exercise-induced intestinal lymphocyte apoptosis by maintaining intracellular glutathione levels and reducing mitochondrial membrane depolarization,” Biochem Biophys Res Commun. 2004 Jul 2;319(3):894-901.

Shungu D., et al. “N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy,” Page 35, 2016 IACFS/ME Conference.

Shungu D., et al. “Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology,” NMR Biomed. 2012 Sep;25(9):1073-87. doi: 10.1002/nbm.2772. Epub 2012 Jan 27.


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